Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers
المؤلفون المشاركون
Rouleau, Etienne
Olschwang, Sylviane
Bourdon, Violaine
Yu, Kai
Caron, Olivier
Lasset, Christine
Baert-Desurmont, Stéphanie
Hutter, Pierre
Buisine, Marie-Pierre
Wang, Qing
Thomas, Gilles
المصدر
Journal of Cancer Epidemiology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-03-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Lynch syndrome is mostly characterized by early-onset colorectal and endometrial adenocarcinomas.
Over 90% of the causal mutations occur in two mismatch repair genes, MSH2 and MLH1.
The aim of this study was to evaluate the age-dependent cancer risk in MSH2 or MLH1 mutation carriers from data of DNA diagnostic laboratories.
To avoid overestimation, evaluation was based on the age-dependent proportion of mutation carriers in asymptomatic first-degree relatives of identified mutation carriers.
Data from 859 such eligible relatives were collected from 8 centers; 387 were found to have inherited the mutation from their relatives.
Age-dependent risks were calculated either using a nonparametric approach for four discrete age groups or assuming a modified Weibull distribution for the dependence of risk on age.
Cancer risk was estimated starting at 28 (25–32 0.68 confidence interval) and to reach near 0.70 at 70 years.
The risks were very similar for MSH2 and MLH1 mutation carriers.
Although not statistically significant, the risk in males appeared to precede that for females by ten years.
This difference needs to be investigated on a larger dataset.
If confirmed, this would indicate that the onset of the colonoscopic surveillance may be different in male and female mutation carriers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olschwang, Sylviane& Yu, Kai& Lasset, Christine& Baert-Desurmont, Stéphanie& Buisine, Marie-Pierre& Wang, Qing…[et al.]. 2009. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-498431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olschwang, Sylviane…[et al.]. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-498431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olschwang, Sylviane& Yu, Kai& Lasset, Christine& Baert-Desurmont, Stéphanie& Buisine, Marie-Pierre& Wang, Qing…[et al.]. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-498431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر