Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers
Joint Authors
Rouleau, Etienne
Olschwang, Sylviane
Bourdon, Violaine
Yu, Kai
Caron, Olivier
Lasset, Christine
Baert-Desurmont, Stéphanie
Hutter, Pierre
Buisine, Marie-Pierre
Wang, Qing
Thomas, Gilles
Source
Journal of Cancer Epidemiology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lynch syndrome is mostly characterized by early-onset colorectal and endometrial adenocarcinomas.
Over 90% of the causal mutations occur in two mismatch repair genes, MSH2 and MLH1.
The aim of this study was to evaluate the age-dependent cancer risk in MSH2 or MLH1 mutation carriers from data of DNA diagnostic laboratories.
To avoid overestimation, evaluation was based on the age-dependent proportion of mutation carriers in asymptomatic first-degree relatives of identified mutation carriers.
Data from 859 such eligible relatives were collected from 8 centers; 387 were found to have inherited the mutation from their relatives.
Age-dependent risks were calculated either using a nonparametric approach for four discrete age groups or assuming a modified Weibull distribution for the dependence of risk on age.
Cancer risk was estimated starting at 28 (25–32 0.68 confidence interval) and to reach near 0.70 at 70 years.
The risks were very similar for MSH2 and MLH1 mutation carriers.
Although not statistically significant, the risk in males appeared to precede that for females by ten years.
This difference needs to be investigated on a larger dataset.
If confirmed, this would indicate that the onset of the colonoscopic surveillance may be different in male and female mutation carriers.
American Psychological Association (APA)
Olschwang, Sylviane& Yu, Kai& Lasset, Christine& Baert-Desurmont, Stéphanie& Buisine, Marie-Pierre& Wang, Qing…[et al.]. 2009. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-498431
Modern Language Association (MLA)
Olschwang, Sylviane…[et al.]. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-498431
American Medical Association (AMA)
Olschwang, Sylviane& Yu, Kai& Lasset, Christine& Baert-Desurmont, Stéphanie& Buisine, Marie-Pierre& Wang, Qing…[et al.]. Age-Dependent Cancer Risk Is Not Different in between MSH2 and MLH1 Mutation Carriers. Journal of Cancer Epidemiology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-498431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498431