Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model
المؤلفون المشاركون
Dixon, Giles
Whyte, Moira K. B.
Billings, Stephen A.
Holmes, Geoffrey R.
Reyes-Aldasoro, Constantino Carlos
Elks, Philip M.
Renshaw, Stephen A.
Kadirkamanathan, Visakan
Anderson, Sean R.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Neutrophils must be removed from inflammatory sites for inflammation to resolve.
Recent work in zebrafish has shown neutrophils can migrate away from inflammatory sites, as well as die in situ.
The signals regulating the process of reverse migration are of considerable interest, but remain unknown.
We wished to study the behaviour of neutrophils during reverse migration, to see whether they moved away from inflamed sites in a directed fashion in the same way as they are recruited or whether the inherent random component of their migration was enough to account for this behaviour.
Using neutrophil-driven photoconvertible Kaede protein in transgenic zebrafish larvae, we were able to specifically label neutrophils at an inflammatory site generated by tailfin transection.
The locations of these neutrophils over time were observed and fitted using regression methods with two separate models: pure-diffusion and drift-diffusion equations.
While a model hypothesis test (the F-test) suggested that the datapoints could be fitted by the drift-diffusion model, implying a fugetaxis process, dynamic simulation of the models suggested that migration of neutrophils away from a wound is better described by a zero-drift, “diffusion” process.
This has implications for understanding the mechanisms of reverse migration and, by extension, neutrophil retention at inflammatory sites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holmes, Geoffrey R.& Dixon, Giles& Anderson, Sean R.& Reyes-Aldasoro, Constantino Carlos& Elks, Philip M.& Billings, Stephen A.…[et al.]. 2012. Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in Hematology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holmes, Geoffrey R.…[et al.]. Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in Hematology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-498471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holmes, Geoffrey R.& Dixon, Giles& Anderson, Sean R.& Reyes-Aldasoro, Constantino Carlos& Elks, Philip M.& Billings, Stephen A.…[et al.]. Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر