Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population
المؤلفون المشاركون
Borah, Prasanta Kumar
Ahmed, Giasuddin
Mahanta, Jagadish
Shankarishan, Priyanka
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Genetic variants of eNOS gene play a significant role in the pathogenesis of hypertension.
Many environmental factors have, also, been implicated in the aetiology of hypertension.
We carried out an age-matched case-control study among adults.
Hypertension was defined according to JNC-VII criteria and eNOS gene polymorphisms were determined by PCR and PCR followed by PCR-RFLP.
eNOS intron 4 aa genotype (adjusted OR 6.81; 95% CI 2.29–20.25) and eNOS 894TT genotype (adjusted OR 7.84; 95% CI 2.57–23.96) were associated with the risk of hypertension.
Tobacco users (either smoking/chewing or both) with eNOS intron 4 aa genotype (OR 14.00: 95% CI 1.20–163.37), eNOS 894GG genotype (OR 5.56: 95% CI 3.72–8.31), and eNOS T-786C CC genotype (OR 9.00: 95% CI 1.14–71.04) were at an increased risk of hypertension.
Similarly a significant gene-environment interaction was observed between individuals consuming alcohol with eNOS intron 4 aa genotype (OR 12.00: 95% CI 1.20–143.73) and eNOS 894GG genotype (OR 1.95: 95% CI 1.35–2.81).
The present study identified few susceptible genotypes of the eNOS gene with the risk of hypertension.
Moreover, the interactive effects between the environmental factors and the risk of hypertension were dependent on the eNOS genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shankarishan, Priyanka& Borah, Prasanta Kumar& Ahmed, Giasuddin& Mahanta, Jagadish. 2014. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shankarishan, Priyanka…[et al.]. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-498539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shankarishan, Priyanka& Borah, Prasanta Kumar& Ahmed, Giasuddin& Mahanta, Jagadish. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر