Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population
Joint Authors
Borah, Prasanta Kumar
Ahmed, Giasuddin
Mahanta, Jagadish
Shankarishan, Priyanka
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Genetic variants of eNOS gene play a significant role in the pathogenesis of hypertension.
Many environmental factors have, also, been implicated in the aetiology of hypertension.
We carried out an age-matched case-control study among adults.
Hypertension was defined according to JNC-VII criteria and eNOS gene polymorphisms were determined by PCR and PCR followed by PCR-RFLP.
eNOS intron 4 aa genotype (adjusted OR 6.81; 95% CI 2.29–20.25) and eNOS 894TT genotype (adjusted OR 7.84; 95% CI 2.57–23.96) were associated with the risk of hypertension.
Tobacco users (either smoking/chewing or both) with eNOS intron 4 aa genotype (OR 14.00: 95% CI 1.20–163.37), eNOS 894GG genotype (OR 5.56: 95% CI 3.72–8.31), and eNOS T-786C CC genotype (OR 9.00: 95% CI 1.14–71.04) were at an increased risk of hypertension.
Similarly a significant gene-environment interaction was observed between individuals consuming alcohol with eNOS intron 4 aa genotype (OR 12.00: 95% CI 1.20–143.73) and eNOS 894GG genotype (OR 1.95: 95% CI 1.35–2.81).
The present study identified few susceptible genotypes of the eNOS gene with the risk of hypertension.
Moreover, the interactive effects between the environmental factors and the risk of hypertension were dependent on the eNOS genotypes.
American Psychological Association (APA)
Shankarishan, Priyanka& Borah, Prasanta Kumar& Ahmed, Giasuddin& Mahanta, Jagadish. 2014. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498539
Modern Language Association (MLA)
Shankarishan, Priyanka…[et al.]. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-498539
American Medical Association (AMA)
Shankarishan, Priyanka& Borah, Prasanta Kumar& Ahmed, Giasuddin& Mahanta, Jagadish. Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Hypertension in an Indian Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498539