Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
المؤلفون المشاركون
Ximenes, Valdecir Farias
Ueda-Nakamura, Tânia
Nishimura, Francielli de Cássia Yukari
Silva, Sueli de Oliveira
Nakamura, Celso Vataru
de Almeida, Ana Carolina
Ratti, Bianca Altrão
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells.
However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity.
Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils.
Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems.
With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus.
Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils.
Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes.
The present results challenge the traditional view of antioxidants as improvers of pathological conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nishimura, Francielli de Cássia Yukari& de Almeida, Ana Carolina& Ratti, Bianca Altrão& Ueda-Nakamura, Tânia& Nakamura, Celso Vataru& Ximenes, Valdecir Farias…[et al.]. 2013. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-498808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nishimura, Francielli de Cássia Yukari…[et al.]. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-498808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nishimura, Francielli de Cássia Yukari& de Almeida, Ana Carolina& Ratti, Bianca Altrão& Ueda-Nakamura, Tânia& Nakamura, Celso Vataru& Ximenes, Valdecir Farias…[et al.]. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-498808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر