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Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
Joint Authors
Ximenes, Valdecir Farias
Ueda-Nakamura, Tânia
Nishimura, Francielli de Cássia Yukari
Silva, Sueli de Oliveira
Nakamura, Celso Vataru
de Almeida, Ana Carolina
Ratti, Bianca Altrão
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells.
However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity.
Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils.
Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems.
With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus.
Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils.
Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes.
The present results challenge the traditional view of antioxidants as improvers of pathological conditions.
American Psychological Association (APA)
Nishimura, Francielli de Cássia Yukari& de Almeida, Ana Carolina& Ratti, Bianca Altrão& Ueda-Nakamura, Tânia& Nakamura, Celso Vataru& Ximenes, Valdecir Farias…[et al.]. 2013. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-498808
Modern Language Association (MLA)
Nishimura, Francielli de Cássia Yukari…[et al.]. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-498808
American Medical Association (AMA)
Nishimura, Francielli de Cássia Yukari& de Almeida, Ana Carolina& Ratti, Bianca Altrão& Ueda-Nakamura, Tânia& Nakamura, Celso Vataru& Ximenes, Valdecir Farias…[et al.]. Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-498808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498808