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Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background
المؤلفون المشاركون
Chiampan, Andrea
Rossi, Andrea
Bergamini, Corinna
Rigolli, Marzia
Cicoira, Mariantonietta
Vassanelli, Corrado
المصدر
Cardiology Research and Practice
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Neurohormonal systems play an important role in chronic heart failure (CHF).
Due to interindividual heterogeneity in the benefits of therapy, it may be hypothesized that polymorphisms of neurohormonal systems may affect left ventricular (LV) remodelling and systolic function.
We aimed to assess whether genetic background of maximally treated CHF patients predicts variations in LV systolic function and volumes.
Methods and Results.
We prospectively studied 131 CHF outpatients on optimal treatment for at least six months.
Echocardiographic evaluations were performed at baseline and after 12 months.
Genotype analysis for ACE I/D, β1adrenergic receptor (AR) Arg389Gly, β2AR Arg16Gly, and β2AR Gln27Glu polymorphisms was performed.
No differences in baseline characteristics were detected among subgroups.
ACE II was a significant predictor of improvement of LV end-diastolic and end-systolic volume (P=.003 and P=.002, respectively) but not of LV ejection fraction (LVEF); β1AR389 GlyGly was related to improvement of LVEF (P=.02) and LV end-systolic volume (P=.01).
The predictive value of polymorphisms remained after adjustment for other clinically significant predictors (P<.05 for all).
Conclusions.
ACE I/D and β1AR Arg389Gly polymorphisms are independent predictors of reverse remodeling and systolic function recovery in CHF patients under optimal treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rigolli, Marzia& Cicoira, Mariantonietta& Bergamini, Corinna& Chiampan, Andrea& Rossi, Andrea& Vassanelli, Corrado. 2011. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rigolli, Marzia…[et al.]. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rigolli, Marzia& Cicoira, Mariantonietta& Bergamini, Corinna& Chiampan, Andrea& Rossi, Andrea& Vassanelli, Corrado. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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