Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background
Joint Authors
Chiampan, Andrea
Rossi, Andrea
Bergamini, Corinna
Rigolli, Marzia
Cicoira, Mariantonietta
Vassanelli, Corrado
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Neurohormonal systems play an important role in chronic heart failure (CHF).
Due to interindividual heterogeneity in the benefits of therapy, it may be hypothesized that polymorphisms of neurohormonal systems may affect left ventricular (LV) remodelling and systolic function.
We aimed to assess whether genetic background of maximally treated CHF patients predicts variations in LV systolic function and volumes.
Methods and Results.
We prospectively studied 131 CHF outpatients on optimal treatment for at least six months.
Echocardiographic evaluations were performed at baseline and after 12 months.
Genotype analysis for ACE I/D, β1adrenergic receptor (AR) Arg389Gly, β2AR Arg16Gly, and β2AR Gln27Glu polymorphisms was performed.
No differences in baseline characteristics were detected among subgroups.
ACE II was a significant predictor of improvement of LV end-diastolic and end-systolic volume (P=.003 and P=.002, respectively) but not of LV ejection fraction (LVEF); β1AR389 GlyGly was related to improvement of LVEF (P=.02) and LV end-systolic volume (P=.01).
The predictive value of polymorphisms remained after adjustment for other clinically significant predictors (P<.05 for all).
Conclusions.
ACE I/D and β1AR Arg389Gly polymorphisms are independent predictors of reverse remodeling and systolic function recovery in CHF patients under optimal treatment.
American Psychological Association (APA)
Rigolli, Marzia& Cicoira, Mariantonietta& Bergamini, Corinna& Chiampan, Andrea& Rossi, Andrea& Vassanelli, Corrado. 2011. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499060
Modern Language Association (MLA)
Rigolli, Marzia…[et al.]. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-499060
American Medical Association (AMA)
Rigolli, Marzia& Cicoira, Mariantonietta& Bergamini, Corinna& Chiampan, Andrea& Rossi, Andrea& Vassanelli, Corrado. Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients : Role of Individual Genetic Background. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-499060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499060