Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets
المؤلفون المشاركون
Batumalaie, Kalaivani
Kumar, Selva
Qvist, Rajes
Ismail, Ikram Shah Bin
Zaman Safi, Sher
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The growing number of people with diabetes worldwide suggests that diabetic retinopathy (DR) and diabetic macular edema (DME) will continue to be sight threatening factors.
The pathogenesis of diabetic retinopathy is a widespread cause of visual impairment in the world and a range of hyperglycemia-linked pathways have been implicated in the initiation and progression of this condition.
Despite understanding the polyol pathway flux, activation of protein kinase C (KPC) isoforms, increased hexosamine pathway flux, and increased advanced glycation end-product (AGE) formation, pathogenic mechanisms underlying diabetes induced vision loss are not fully understood.
The purpose of this paper is to review molecular mechanisms that regulate cell survival and apoptosis of retinal cells and discuss new and exciting therapeutic targets with comparison to the old and inefficient preventive strategies.
This review highlights the recent advancements in understanding hyperglycemia-induced biochemical and molecular alterations, systemic metabolic factors, and aberrant activation of signaling cascades that ultimately lead to activation of a number of transcription factors causing functional and structural damage to retinal cells.
It also reviews the established interventions and emerging molecular targets to avert diabetic retinopathy and its associated risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaman Safi, Sher& Qvist, Rajes& Kumar, Selva& Batumalaie, Kalaivani& Ismail, Ikram Shah Bin. 2014. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-499096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaman Safi, Sher…[et al.]. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-499096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaman Safi, Sher& Qvist, Rajes& Kumar, Selva& Batumalaie, Kalaivani& Ismail, Ikram Shah Bin. Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-499096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر