Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited
المؤلفون المشاركون
Yang, Jay
Zonder, Jeffrey A.
Terebelo, Howard R.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The treatment of myeloma has undergone extraordinary improvements in the past half century.
These advances have been accompanied by a concern for secondary primary malignancies (SPMs).
It has been known for decades that extended therapy with alkylating chemotherapy agents, such as melphalan, carries an increased risk of therapy-related myelodysplastic syndrome and/or acute myeloid leukemia (t-MDS/AML), with a cumulative risk as high as 10–15%.
High-dose chemotherapy with autologous stem cell support became widely accepted for myeloma in the 1990s.
Despite the use of high doses of melphalan, the risk of t-MDS/AML with this procedure is estimated to be less than 5%, with much of this risk attributable to pretransplant therapy.
Recently, lenalidomide has come under scrutiny for its possible association with SPMs.
It is too soon to declare a causal relationship at this time, but there appears to be an increased number of SPMs in reports from several studies using lenalidomide maintenance.
Current studies should be amended and future studies planned to better define the risk of SPMs and the risk factors and mechanisms for its development.
Patients should be educated regarding this potential concern but the current use of lenalidomide should not generally be altered until further data are available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Jay& Terebelo, Howard R.& Zonder, Jeffrey A.. 2012. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-499126
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Jay…[et al.]. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-499126
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Jay& Terebelo, Howard R.& Zonder, Jeffrey A.. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-499126
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499126
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر