Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited
Joint Authors
Yang, Jay
Zonder, Jeffrey A.
Terebelo, Howard R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The treatment of myeloma has undergone extraordinary improvements in the past half century.
These advances have been accompanied by a concern for secondary primary malignancies (SPMs).
It has been known for decades that extended therapy with alkylating chemotherapy agents, such as melphalan, carries an increased risk of therapy-related myelodysplastic syndrome and/or acute myeloid leukemia (t-MDS/AML), with a cumulative risk as high as 10–15%.
High-dose chemotherapy with autologous stem cell support became widely accepted for myeloma in the 1990s.
Despite the use of high doses of melphalan, the risk of t-MDS/AML with this procedure is estimated to be less than 5%, with much of this risk attributable to pretransplant therapy.
Recently, lenalidomide has come under scrutiny for its possible association with SPMs.
It is too soon to declare a causal relationship at this time, but there appears to be an increased number of SPMs in reports from several studies using lenalidomide maintenance.
Current studies should be amended and future studies planned to better define the risk of SPMs and the risk factors and mechanisms for its development.
Patients should be educated regarding this potential concern but the current use of lenalidomide should not generally be altered until further data are available.
American Psychological Association (APA)
Yang, Jay& Terebelo, Howard R.& Zonder, Jeffrey A.. 2012. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-499126
Modern Language Association (MLA)
Yang, Jay…[et al.]. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-499126
American Medical Association (AMA)
Yang, Jay& Terebelo, Howard R.& Zonder, Jeffrey A.. Secondary Primary Malignancies in Multiple Myeloma : An Old Nemesis Revisited. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-499126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499126