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BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK12 Signaling Pathway
المؤلفون المشاركون
Liang, Rixin
Wang, Lan
Yang, Hongjun
Zhang, Fangbo
Tang, Shihuan
Xu, Haiyu
Zhao, Ye
Huang, Bin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Buchang naoxintong capsule (BNC) is a traditional Chinese medicine approved for the treatment of cerebrovascular and cardiovascular diseases.
However, little is known about the specific protective function or mechanism by which BNC protects against myocardial injury.
This research was designed to investigate the cardioprotective effects of BNC in vitro model of hydrogen peroxide (H2O2)-induced H9c2 rat cardiomyoblasts.
BNC intestinal absorption liquid was used in this study instead of drug-containing serum or extracting solution.
Our study revealed that BNC preconditioning enhanced antioxidant function by increasing the activities of total-antioxygen capacity, total-superoxide dismutase, and catalase and by decreasing the production of reactive oxygen species and malondialdehyde.
BNC preconditioning also activated extracellular signal-regulated kinases (ERK1/2) and inhibited apoptosis-related proteins such as poly ADP-ribose polymerase (PARP) and caspase-3.
Additionally, preincubation with BNC reduced intracellular Ca2+ concentration, improved mitochondrial membrane potential, and decreased the apoptosis rate of H9c2 cells in a dose-dependent manner.
These data demonstrated that BNC protects H9c2 cardiomyoblasts from H2O2-induced oxidative injury by increasing antioxidant abilities, activating ERK1/2, and blocking Ca2+-dependent and mitochondria-mediated apoptosis.
Based on our results, the potency of BNC for protecting H9c2 cells from oxidative damage is comparable to that of trimetazidine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Fangbo& Huang, Bin& Zhao, Ye& Tang, Shihuan& Xu, Haiyu& Wang, Lan…[et al.]. 2013. BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-499240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Fangbo…[et al.]. BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-499240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Fangbo& Huang, Bin& Zhao, Ye& Tang, Shihuan& Xu, Haiyu& Wang, Lan…[et al.]. BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-499240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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