Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats

المؤلفون المشاركون

Hsiao, George
Yen, Ting-Lin
Chou, Duen-Suey
Sheu, Joen-Rong
Jayakumar, Thanasekaran
Chen, Jui-Tai
Wu, Chih-Jen

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-11-04

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Tao-Hong-Si-Wu-Tang (THSWT) is a famous traditional Chinese medicine (TMC).

In the present study, oral administration of THSWT (0.7 and 1.4 g kg−1day−1) for 14 days before MCAO dose-dependently attenuated focal cerebral ischemia in rats.

MCAO-induced focal cerebral ischemia was associated with increases in hypoxia-inducible factor (HIF)-1α, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, and active caspase-3 expressions in ischemic regions.

These expressions were obviously inhibited by 0.7 g kg−1day−1 THSWT treatment.

In addition, THSWT inhibited platelet aggregation stimulated by collagen in washed platelets.

In an in vivo study, THSWT (16 g kg−1) significantly prolonged platelet plug formation in mice.

However, THSWT (20 and 40 μg mL−1) did not significantly reduce the electron spin resonance (ESR) signal intensity of hydroxyl radical (OH•) formation.

In conclusion, the most important findings of this study demonstrate for the first time that THSWT possesses potent neuroprotective activity against MCAO-induced focal cerebral ischemia in vivo.

This effect may be mediated, at least in part, by the inhibition of both HIF-1α and TNF-α activation, followed by the inhibition of inflammatory responses (i.e., iNOS expression), apoptosis formation (active caspase-3), and platelet activation, resulting in a reduction in the infarct volume in ischemia-reperfusion brain injury.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Chih-Jen& Chen, Jui-Tai& Yen, Ting-Lin& Jayakumar, Thanasekaran& Chou, Duen-Suey& Hsiao, George…[et al.]. 2010. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499265

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Chih-Jen…[et al.]. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499265

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Chih-Jen& Chen, Jui-Tai& Yen, Ting-Lin& Jayakumar, Thanasekaran& Chou, Duen-Suey& Hsiao, George…[et al.]. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499265

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-499265