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Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats
Joint Authors
Hsiao, George
Yen, Ting-Lin
Chou, Duen-Suey
Sheu, Joen-Rong
Jayakumar, Thanasekaran
Chen, Jui-Tai
Wu, Chih-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tao-Hong-Si-Wu-Tang (THSWT) is a famous traditional Chinese medicine (TMC).
In the present study, oral administration of THSWT (0.7 and 1.4 g kg−1day−1) for 14 days before MCAO dose-dependently attenuated focal cerebral ischemia in rats.
MCAO-induced focal cerebral ischemia was associated with increases in hypoxia-inducible factor (HIF)-1α, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, and active caspase-3 expressions in ischemic regions.
These expressions were obviously inhibited by 0.7 g kg−1day−1 THSWT treatment.
In addition, THSWT inhibited platelet aggregation stimulated by collagen in washed platelets.
In an in vivo study, THSWT (16 g kg−1) significantly prolonged platelet plug formation in mice.
However, THSWT (20 and 40 μg mL−1) did not significantly reduce the electron spin resonance (ESR) signal intensity of hydroxyl radical (OH•) formation.
In conclusion, the most important findings of this study demonstrate for the first time that THSWT possesses potent neuroprotective activity against MCAO-induced focal cerebral ischemia in vivo.
This effect may be mediated, at least in part, by the inhibition of both HIF-1α and TNF-α activation, followed by the inhibition of inflammatory responses (i.e., iNOS expression), apoptosis formation (active caspase-3), and platelet activation, resulting in a reduction in the infarct volume in ischemia-reperfusion brain injury.
American Psychological Association (APA)
Wu, Chih-Jen& Chen, Jui-Tai& Yen, Ting-Lin& Jayakumar, Thanasekaran& Chou, Duen-Suey& Hsiao, George…[et al.]. 2010. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499265
Modern Language Association (MLA)
Wu, Chih-Jen…[et al.]. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499265
American Medical Association (AMA)
Wu, Chih-Jen& Chen, Jui-Tai& Yen, Ting-Lin& Jayakumar, Thanasekaran& Chou, Duen-Suey& Hsiao, George…[et al.]. Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499265