Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity
المؤلفون المشاركون
Leevy, W. Matthew
Unger, Alexandra
Smith, Bryan A.
Negin, Saeedeh
Gokel, George W.
المصدر
International Journal of Biomedical Imaging
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Hydraphiles are a class of synthetic ion channels that now have a twenty-year history of analysis and success.
In early studies, these compounds were rigorously validated in a wide range of in vitro assays including liposomal ion flow detected by NMR or ion-selective electrodes, as well as biophysical experiments in planar bilayers.
During the past decade, biological activity was observed for these compounds including toxicity to bacteria, yeast, and mammalian cells due to stress caused by the disruption of ion homeostasis.
The channel mechanism was verified in cells using membrane polarity sensitive dyes, as well as patch clamping studies.
This body of work has provided a solid foundation with which hydraphiles have recently demonstrated acute biological toxicity in the muscle tissue of living mice, as measured by whole animal fluorescence imaging and histological studies.
Here we review the critical structure-activity relationships in the hydraphile family of compounds and the in vitro and in cellulo experiments that have validated their channel behavior.
This report culminates with a description of recently reported efforts in which these molecules have demonstrated activity in living mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Negin, Saeedeh& Smith, Bryan A.& Unger, Alexandra& Leevy, W. Matthew& Gokel, George W.. 2013. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499306
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Negin, Saeedeh…[et al.]. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-499306
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Negin, Saeedeh& Smith, Bryan A.& Unger, Alexandra& Leevy, W. Matthew& Gokel, George W.. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499306
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499306
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر