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Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity
Joint Authors
Leevy, W. Matthew
Unger, Alexandra
Smith, Bryan A.
Negin, Saeedeh
Gokel, George W.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hydraphiles are a class of synthetic ion channels that now have a twenty-year history of analysis and success.
In early studies, these compounds were rigorously validated in a wide range of in vitro assays including liposomal ion flow detected by NMR or ion-selective electrodes, as well as biophysical experiments in planar bilayers.
During the past decade, biological activity was observed for these compounds including toxicity to bacteria, yeast, and mammalian cells due to stress caused by the disruption of ion homeostasis.
The channel mechanism was verified in cells using membrane polarity sensitive dyes, as well as patch clamping studies.
This body of work has provided a solid foundation with which hydraphiles have recently demonstrated acute biological toxicity in the muscle tissue of living mice, as measured by whole animal fluorescence imaging and histological studies.
Here we review the critical structure-activity relationships in the hydraphile family of compounds and the in vitro and in cellulo experiments that have validated their channel behavior.
This report culminates with a description of recently reported efforts in which these molecules have demonstrated activity in living mice.
American Psychological Association (APA)
Negin, Saeedeh& Smith, Bryan A.& Unger, Alexandra& Leevy, W. Matthew& Gokel, George W.. 2013. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499306
Modern Language Association (MLA)
Negin, Saeedeh…[et al.]. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-499306
American Medical Association (AMA)
Negin, Saeedeh& Smith, Bryan A.& Unger, Alexandra& Leevy, W. Matthew& Gokel, George W.. Hydraphiles : A Rigorously Studied Class of Synthetic Channel Compounds with In Vivo Activity. International Journal of Biomedical Imaging. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-499306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499306