![](/images/graphics-bg.png)
Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer
المؤلفون المشاركون
Yang, Xiaozhong
Gao, Chengcheng
Ren, Chengcheng
Xie, Rui
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the involvement of Dickkopf-1 expression in gastric cancer.
Methods.
Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients.
Results.
Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues.
Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors.
Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression.
In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate.
Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer.
Conclusion.
A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course.
Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer.
This is the first report describing the involvement of Dickkopf-1 in gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Chengcheng& Xie, Rui& Ren, Chengcheng& Yang, Xiaozhong. 2012. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Chengcheng…[et al.]. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-499394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Chengcheng& Xie, Rui& Ren, Chengcheng& Yang, Xiaozhong. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)