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Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer
Joint Authors
Yang, Xiaozhong
Gao, Chengcheng
Ren, Chengcheng
Xie, Rui
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To investigate the involvement of Dickkopf-1 expression in gastric cancer.
Methods.
Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients.
Results.
Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues.
Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors.
Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression.
In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate.
Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer.
Conclusion.
A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course.
Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer.
This is the first report describing the involvement of Dickkopf-1 in gastric cancer.
American Psychological Association (APA)
Gao, Chengcheng& Xie, Rui& Ren, Chengcheng& Yang, Xiaozhong. 2012. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499394
Modern Language Association (MLA)
Gao, Chengcheng…[et al.]. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-499394
American Medical Association (AMA)
Gao, Chengcheng& Xie, Rui& Ren, Chengcheng& Yang, Xiaozhong. Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499394