Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis
المؤلفون المشاركون
Capone, Loredana
Porzia, Alessandra
Di Summa, Alfonsina
Moling, Oswald
Capozzi, Antonella
Piccin, Andrea
Mian, Peter
Binazzi, Raffaella
Gandini, Lathá
Stuefer, Josef
Sorice, Maurizio
Rimenti, Giovanni
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The immune system protects the organism from foreign invaders and foreign substances and is involved in physiological functions that range from tissue repair to neurocognition.
However, an excessive or dysregulated immune response can cause immunopathology and disease.
A 39-year-old man was affected by severe hepatosplenic schistosomiasis mansoni and by amyotrophic lateral sclerosis.
One question that arose was, whether there was a relation between the parasitic and the neurodegenerative disease.
IL-17, a proinflammatory cytokine, is produced mainly by T helper-17 CD4 cells, a recently discovered new lineage of effector CD4 T cells.
Experimental mouse models of schistosomiasis have shown that IL-17 is a key player in the immunopathology of schistosomiasis.
There are also reports that suggest that IL-17 might have an important role in the pathogenesis of amyotrophic lateral sclerosis.
It is hypothesized that the factors that might have led to increased IL-17 in the hepatosplenic schistosomiasis mansoni might also have contributed to the development of amyotrophic lateral sclerosis in the described patient.
A multitude of environmental factors, including infections, xenobiotic substances, intestinal microbiota, and vitamin D deficiency, that are able to induce a proinflammatory immune response polarization, might favor the development of amyotrophic lateral sclerosis in predisposed individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moling, Oswald& Di Summa, Alfonsina& Capone, Loredana& Stuefer, Josef& Piccin, Andrea& Porzia, Alessandra…[et al.]. 2014. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moling, Oswald…[et al.]. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-499416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moling, Oswald& Di Summa, Alfonsina& Capone, Loredana& Stuefer, Josef& Piccin, Andrea& Porzia, Alessandra…[et al.]. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر