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Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis
Joint Authors
Capone, Loredana
Porzia, Alessandra
Di Summa, Alfonsina
Moling, Oswald
Capozzi, Antonella
Piccin, Andrea
Mian, Peter
Binazzi, Raffaella
Gandini, Lathá
Stuefer, Josef
Sorice, Maurizio
Rimenti, Giovanni
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The immune system protects the organism from foreign invaders and foreign substances and is involved in physiological functions that range from tissue repair to neurocognition.
However, an excessive or dysregulated immune response can cause immunopathology and disease.
A 39-year-old man was affected by severe hepatosplenic schistosomiasis mansoni and by amyotrophic lateral sclerosis.
One question that arose was, whether there was a relation between the parasitic and the neurodegenerative disease.
IL-17, a proinflammatory cytokine, is produced mainly by T helper-17 CD4 cells, a recently discovered new lineage of effector CD4 T cells.
Experimental mouse models of schistosomiasis have shown that IL-17 is a key player in the immunopathology of schistosomiasis.
There are also reports that suggest that IL-17 might have an important role in the pathogenesis of amyotrophic lateral sclerosis.
It is hypothesized that the factors that might have led to increased IL-17 in the hepatosplenic schistosomiasis mansoni might also have contributed to the development of amyotrophic lateral sclerosis in the described patient.
A multitude of environmental factors, including infections, xenobiotic substances, intestinal microbiota, and vitamin D deficiency, that are able to induce a proinflammatory immune response polarization, might favor the development of amyotrophic lateral sclerosis in predisposed individuals.
American Psychological Association (APA)
Moling, Oswald& Di Summa, Alfonsina& Capone, Loredana& Stuefer, Josef& Piccin, Andrea& Porzia, Alessandra…[et al.]. 2014. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499416
Modern Language Association (MLA)
Moling, Oswald…[et al.]. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-499416
American Medical Association (AMA)
Moling, Oswald& Di Summa, Alfonsina& Capone, Loredana& Stuefer, Josef& Piccin, Andrea& Porzia, Alessandra…[et al.]. Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis : A Hypothesis. Case Reports in Immunology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499416