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Human Genomic Deletions Generated by SVA-Associated Events
المؤلفون المشاركون
Han, Kyudong
Lee, Jungnam
Ha, Jungsu
Son, Seung-Yeol
المصدر
Comparative and Functional Genomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mobile elements are responsible for half of the human genome.
Among the elements, L1 and Alu are most ubiquitous.
They use L1 enzymatic machinery to move in their host genomes.
A significant amount of research has been conducted about these two elements.
The results showed that these two elements have played important roles in generating genomic variations between human and chimpanzee lineages and even within a species, through various mechanisms.
SVA elements are a third type of mobile element which uses the L1 enzymatic machinery to propagate in the human genome but has not been studied much relative to the other elements.
Here, we attempt the first identification of the human genomic deletions caused by SVA elements, through the comparison of human and chimpanzee genome sequences.
We identified 13 SVA recombination-associated deletions (SRADs) and 13 SVA insertion-mediated deletions (SIMDs) in the human genome and characterized them, focusing on deletion size and the mechanisms causing the events.
The results showed that the SRADs and SIMDs have deleted 15,752 and 30,785 bp, respectively, in the human genome since the divergence of human and chimpanzee and that SRADs were caused by two different mechanisms, nonhomologous end joining and nonallelic homologous recombination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jungnam& Ha, Jungsu& Son, Seung-Yeol& Han, Kyudong. 2012. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499638
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jungnam…[et al.]. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-499638
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jungnam& Ha, Jungsu& Son, Seung-Yeol& Han, Kyudong. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499638
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499638
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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