Human Genomic Deletions Generated by SVA-Associated Events
Joint Authors
Han, Kyudong
Lee, Jungnam
Ha, Jungsu
Son, Seung-Yeol
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mobile elements are responsible for half of the human genome.
Among the elements, L1 and Alu are most ubiquitous.
They use L1 enzymatic machinery to move in their host genomes.
A significant amount of research has been conducted about these two elements.
The results showed that these two elements have played important roles in generating genomic variations between human and chimpanzee lineages and even within a species, through various mechanisms.
SVA elements are a third type of mobile element which uses the L1 enzymatic machinery to propagate in the human genome but has not been studied much relative to the other elements.
Here, we attempt the first identification of the human genomic deletions caused by SVA elements, through the comparison of human and chimpanzee genome sequences.
We identified 13 SVA recombination-associated deletions (SRADs) and 13 SVA insertion-mediated deletions (SIMDs) in the human genome and characterized them, focusing on deletion size and the mechanisms causing the events.
The results showed that the SRADs and SIMDs have deleted 15,752 and 30,785 bp, respectively, in the human genome since the divergence of human and chimpanzee and that SRADs were caused by two different mechanisms, nonhomologous end joining and nonallelic homologous recombination.
American Psychological Association (APA)
Lee, Jungnam& Ha, Jungsu& Son, Seung-Yeol& Han, Kyudong. 2012. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499638
Modern Language Association (MLA)
Lee, Jungnam…[et al.]. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-499638
American Medical Association (AMA)
Lee, Jungnam& Ha, Jungsu& Son, Seung-Yeol& Han, Kyudong. Human Genomic Deletions Generated by SVA-Associated Events. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-499638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499638