Evaluation of Genetic Polymorphism of Leishmania (V.) braziliensis Isolates Obtained from the Same Patient before and after Therapeutic Failure or Reactivation of Cutaneous Lesions
المؤلفون المشاركون
Fernandes Pimentel, Maria Ines
de Freitas Campos Miranda, Luciana
Madeira, Maria de Fátima
Conceição-Silva, Fatima
Helena da Silva Barros, Juliana
Schubach, Armando de Oliveira
Baptista, Cibele
da Silva Pacheco, Raquel
Guimarães de Souza Pinto, Andressa
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate genetic polymorphism in Leishmania braziliensis population previously typed through isoenzyme electrophoresis, isolated from the same patient in two different moments: (A) before the beginning of treatment and (B) after treatment failure to meglumine antimoniate or reactivation after successful initial treatment.
Fifteen pairs of isolates were assessed using the polymorphic molecular marker LSSP-PCR and following the phenetic analysis.
The genetic profiles of the 30 samples were grouped in four clusters.
Only two patients presented total identity in the A and B isolates.
Most isolates presented similarity coefficients varying from 0.63 to 0.91.
In this group of patients genetic polymorphisms could be observed indicating low similarity between the pairs of isolates.
The results demonstrate the existence of genetic polymorphism between the samples isolated before treatment and after reactivation or treatment failure, suggesting a possible differentiation of the structure of the original parasite population which could be involved in the mechanisms of resistance to treatment or reactivation of lesions in the ATL.
This phenomenon is important, although other factors also could be involved in this context and are discussed in this paper.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baptista, Cibele& Schubach, Armando de Oliveira& Madeira, Maria de Fátima& de Freitas Campos Miranda, Luciana& Guimarães de Souza Pinto, Andressa& Helena da Silva Barros, Juliana…[et al.]. 2012. Evaluation of Genetic Polymorphism of Leishmania (V.) braziliensis Isolates Obtained from the Same Patient before and after Therapeutic Failure or Reactivation of Cutaneous Lesions. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-499714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baptista, Cibele…[et al.]. Evaluation of Genetic Polymorphism of Leishmania (V.) braziliensis Isolates Obtained from the Same Patient before and after Therapeutic Failure or Reactivation of Cutaneous Lesions. Journal of Tropical Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-499714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baptista, Cibele& Schubach, Armando de Oliveira& Madeira, Maria de Fátima& de Freitas Campos Miranda, Luciana& Guimarães de Souza Pinto, Andressa& Helena da Silva Barros, Juliana…[et al.]. Evaluation of Genetic Polymorphism of Leishmania (V.) braziliensis Isolates Obtained from the Same Patient before and after Therapeutic Failure or Reactivation of Cutaneous Lesions. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-499714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر