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Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors
المؤلفون المشاركون
Han, Ho-Jae
Roh, Dae-Hyun
Kang, Suk-Yun
Kim, Hyun-Woo
Beitz, Alvin J.
Lee, Jang-Hern
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The injection of diluted bee venom (DBV) into an acupoint has been used traditionally in eastern medicine to treat a variety of inflammatory chronic pain conditions.
We have previously shown that DBV had a potent antinociceptive efficacy in several rodent pain models.
However, the peripheral mechanisms underlying DBV-induced antinociception remain unclear.
The present study was designed to investigate the role of peripheral epinephrine on the DBV-induced antinociceptive effect in the mouse formalin assay.
Adrenalectomy significantly enhanced the antinociceptive effect of DBV during the late phase of the formalin test, while chemical sympathectomy had no effect.
Intraperitoneal injection of epinephrine blocked this adrenalectomy-induced enhancement of the DBV-induced antinociceptive effect.
Moreover, injection of a phenylethanolamine N-methyltransferase (PNMT) inhibitor enhanced the DBV-induced antinociceptive effect.
Administration of nonselective β-adrenergic antagonists also significantly potentiated this DBV-induced antinociception, in a manner similar to adrenalectomy.
These results demonstrate that the antinociceptive effect of DBV treatment can be significantly enhanced by modulation of adrenal medulla-derived epinephrine and this effect is mediated by peripheral β-adrenoceptors.
Thus, DBV acupoint stimulation in combination with inhibition of peripheral β-adrenoceptors could be a potentially novel strategy for the management of inflammatory pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Suk-Yun& Roh, Dae-Hyun& Kim, Hyun-Woo& Han, Ho-Jae& Beitz, Alvin J.& Lee, Jang-Hern. 2013. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499781
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Suk-Yun…[et al.]. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499781
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Suk-Yun& Roh, Dae-Hyun& Kim, Hyun-Woo& Han, Ho-Jae& Beitz, Alvin J.& Lee, Jang-Hern. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499781
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499781
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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