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Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors
Joint Authors
Han, Ho-Jae
Roh, Dae-Hyun
Kang, Suk-Yun
Kim, Hyun-Woo
Beitz, Alvin J.
Lee, Jang-Hern
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The injection of diluted bee venom (DBV) into an acupoint has been used traditionally in eastern medicine to treat a variety of inflammatory chronic pain conditions.
We have previously shown that DBV had a potent antinociceptive efficacy in several rodent pain models.
However, the peripheral mechanisms underlying DBV-induced antinociception remain unclear.
The present study was designed to investigate the role of peripheral epinephrine on the DBV-induced antinociceptive effect in the mouse formalin assay.
Adrenalectomy significantly enhanced the antinociceptive effect of DBV during the late phase of the formalin test, while chemical sympathectomy had no effect.
Intraperitoneal injection of epinephrine blocked this adrenalectomy-induced enhancement of the DBV-induced antinociceptive effect.
Moreover, injection of a phenylethanolamine N-methyltransferase (PNMT) inhibitor enhanced the DBV-induced antinociceptive effect.
Administration of nonselective β-adrenergic antagonists also significantly potentiated this DBV-induced antinociception, in a manner similar to adrenalectomy.
These results demonstrate that the antinociceptive effect of DBV treatment can be significantly enhanced by modulation of adrenal medulla-derived epinephrine and this effect is mediated by peripheral β-adrenoceptors.
Thus, DBV acupoint stimulation in combination with inhibition of peripheral β-adrenoceptors could be a potentially novel strategy for the management of inflammatory pain.
American Psychological Association (APA)
Kang, Suk-Yun& Roh, Dae-Hyun& Kim, Hyun-Woo& Han, Ho-Jae& Beitz, Alvin J.& Lee, Jang-Hern. 2013. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499781
Modern Language Association (MLA)
Kang, Suk-Yun…[et al.]. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499781
American Medical Association (AMA)
Kang, Suk-Yun& Roh, Dae-Hyun& Kim, Hyun-Woo& Han, Ho-Jae& Beitz, Alvin J.& Lee, Jang-Hern. Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test : Involvement of Peripheral β-Adrenoceptors. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499781