Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients

المؤلفون المشاركون

Hamouda, Halah E.
al-Nouby, Khulud A.
Abd al-Hamid, Amal H.
Najm, Usamah E.
al-Jamal, Usama M.
Ismail, Ghadah M.

المصدر

Journal of the Egyptian Society of Parasitology

العدد

المجلد 38، العدد 3 (31 ديسمبر/كانون الأول 2008)، ص ص. 991-1006، 16ص.

الناشر

الجمعية المصرية لعلم الطفيليات

تاريخ النشر

2008-12-31

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

This work was carried out on three groups, 30 Egyptian patients with Schistosoma haematobium (S.

haematobium) with bladder cancer( 15), and without bladder cancer (15), as well as 15 normal individuals as a control.

All the individuals were subjected to measurement of serum level of GST by using ELISA technique and genotyping for GST-M1 & GST-T1 using PCR technique.

The results proved that GST serum level was significantly deceased in S.

haematobium patients with bladder cancer as compared to the other groups.

The PCR results for the GST-M1 & GST-T1 genotyping showed 4 categories, (M1 + ve / T1 + ve, M1 + ve / T1-ve, M1 – ve / T1 + ve, M1 – ve / T1 / - ve).

There was a significant decrease in enzyme levels in patients with GST-M1- ve / T1-ve as compared to the other categories.

Besides, there was a significant increased risk for bladder cancer development in patients with combined gene deletion (OR = 40) which represented mainly in S.

haematobium patients with bladder cancer (53.3 % = M1 – ve / T1 - ve).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

al-Nouby, Khulud A.& Abd al-Hamid, Amal H.& Najm, Usamah E.& Hamouda, Halah E.& al-Jamal, Usama M.& Ismail, Ghadah M.. 2008. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 3, pp.991-1006.
https://search.emarefa.net/detail/BIM-49980

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

al-Nouby, Khulud A.…[et al.]. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology Vol. 38, no. 3 (Dec. 2008), pp.991-1006.
https://search.emarefa.net/detail/BIM-49980

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

al-Nouby, Khulud A.& Abd al-Hamid, Amal H.& Najm, Usamah E.& Hamouda, Halah E.& al-Jamal, Usama M.& Ismail, Ghadah M.. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 3, pp.991-1006.
https://search.emarefa.net/detail/BIM-49980

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1002-1006

رقم السجل

BIM-49980