Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients
Joint Authors
Hamouda, Halah E.
al-Nouby, Khulud A.
Abd al-Hamid, Amal H.
Najm, Usamah E.
al-Jamal, Usama M.
Ismail, Ghadah M.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 3 (31 Dec. 2008), pp.991-1006, 16 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-12-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Topics
Abstract EN
This work was carried out on three groups, 30 Egyptian patients with Schistosoma haematobium (S.
haematobium) with bladder cancer( 15), and without bladder cancer (15), as well as 15 normal individuals as a control.
All the individuals were subjected to measurement of serum level of GST by using ELISA technique and genotyping for GST-M1 & GST-T1 using PCR technique.
The results proved that GST serum level was significantly deceased in S.
haematobium patients with bladder cancer as compared to the other groups.
The PCR results for the GST-M1 & GST-T1 genotyping showed 4 categories, (M1 + ve / T1 + ve, M1 + ve / T1-ve, M1 – ve / T1 + ve, M1 – ve / T1 / - ve).
There was a significant decrease in enzyme levels in patients with GST-M1- ve / T1-ve as compared to the other categories.
Besides, there was a significant increased risk for bladder cancer development in patients with combined gene deletion (OR = 40) which represented mainly in S.
haematobium patients with bladder cancer (53.3 % = M1 – ve / T1 - ve).
American Psychological Association (APA)
al-Nouby, Khulud A.& Abd al-Hamid, Amal H.& Najm, Usamah E.& Hamouda, Halah E.& al-Jamal, Usama M.& Ismail, Ghadah M.. 2008. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 3, pp.991-1006.
https://search.emarefa.net/detail/BIM-49980
Modern Language Association (MLA)
al-Nouby, Khulud A.…[et al.]. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology Vol. 38, no. 3 (Dec. 2008), pp.991-1006.
https://search.emarefa.net/detail/BIM-49980
American Medical Association (AMA)
al-Nouby, Khulud A.& Abd al-Hamid, Amal H.& Najm, Usamah E.& Hamouda, Halah E.& al-Jamal, Usama M.& Ismail, Ghadah M.. Genetic polymorphism of glutathione stransferase schistosomiasis -associated bladder cancer in egyptian patients. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 3, pp.991-1006.
https://search.emarefa.net/detail/BIM-49980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1002-1006
Record ID
BIM-49980