In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients

المؤلفون المشاركون

Kappler, Matthias
Hector, Andreas
Griese, Matthias

المصدر

Mediators of Inflammation

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-06-16

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Inhaled antibiotics are commonly used in the treatment of cystic fibrosis lung disease.

A previous study suggested neutrophil elastase activation by colistin in vitro.

Here, we investigated direct effects of the commonly used antibiotics colistin and tobramycin on neutrophil elastase activity.

Methods.

Neutrophil elastase was measured spectrophotometrically.

The antibiotics colistin and tobramycin were added in different concentrations with or without the addition of albumin.

Results.

Generally, neutrophil elastase activity was lower in the absence of albumin compared to its presence.

Both antibiotics, colistin and tobramycin, had inhibitory effects on neutrophil elastase activity except for high concentrations of colistin when albumin was absent.

Conclusions.

Our results suggest inhibitory effects of colistin and tobramycin in vitro.

There was a clear dependency of neutrophil elastase measurements on the presence of albumin.

Clinical studies are needed to investigate potential direct effects of inhaled antibiotics on neutrophil elastase activity in cystic fibrosis airways.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hector, Andreas& Kappler, Matthias& Griese, Matthias. 2010. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-499848

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hector, Andreas…[et al.]. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-499848

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hector, Andreas& Kappler, Matthias& Griese, Matthias. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-499848

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-499848