In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients
Joint Authors
Kappler, Matthias
Hector, Andreas
Griese, Matthias
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Inhaled antibiotics are commonly used in the treatment of cystic fibrosis lung disease.
A previous study suggested neutrophil elastase activation by colistin in vitro.
Here, we investigated direct effects of the commonly used antibiotics colistin and tobramycin on neutrophil elastase activity.
Methods.
Neutrophil elastase was measured spectrophotometrically.
The antibiotics colistin and tobramycin were added in different concentrations with or without the addition of albumin.
Results.
Generally, neutrophil elastase activity was lower in the absence of albumin compared to its presence.
Both antibiotics, colistin and tobramycin, had inhibitory effects on neutrophil elastase activity except for high concentrations of colistin when albumin was absent.
Conclusions.
Our results suggest inhibitory effects of colistin and tobramycin in vitro.
There was a clear dependency of neutrophil elastase measurements on the presence of albumin.
Clinical studies are needed to investigate potential direct effects of inhaled antibiotics on neutrophil elastase activity in cystic fibrosis airways.
American Psychological Association (APA)
Hector, Andreas& Kappler, Matthias& Griese, Matthias. 2010. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-499848
Modern Language Association (MLA)
Hector, Andreas…[et al.]. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-499848
American Medical Association (AMA)
Hector, Andreas& Kappler, Matthias& Griese, Matthias. In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-499848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499848