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Hydroxyl Radical and Its Scavengers in Health and Disease
المؤلف
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
It is generally believed that diseases caused by oxidative stress should be treated with antioxidants.
However, clinical trials with such antioxidants as ascorbic acid and vitamin E, failed to produce the expected beneficial results.
On the other hand, important biomolecules can be modified by the introduction of oxygen atoms by means of non-oxidative hydroxyl radicals.
In addition, hydroxyl radicals can reduce disulfide bonds in proteins, specifically fibrinogen, resulting in their unfolding and scrambled refolding into abnormal spatial configurations.
Consequences of this reaction are observed in many diseases such as atherosclerosis, cancer and neurological disorders, and can be prevented by the action of non-reducing substances.
Moreover, many therapeutic substances, traditionally classified as antioxidants, accept electrons and thus are effective oxidants.
It is described in this paper that hydroxyl radicals can be generated by ferric ions without any oxidizing agent.
In view of the well-known damaging effect of poorly chelated iron in the human body, numerous natural products containing iron binding agents can be essential in the maintenance of human health.
However, beneficial effects of the great number of phytochemicals that are endowed with hydroxyl radical scavenging and/or iron chelating activities should not be considered as a proof for oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lipinski, Boguslaw. 2011. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lipinski, Boguslaw. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lipinski, Boguslaw. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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