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Hydroxyl Radical and Its Scavengers in Health and Disease
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
It is generally believed that diseases caused by oxidative stress should be treated with antioxidants.
However, clinical trials with such antioxidants as ascorbic acid and vitamin E, failed to produce the expected beneficial results.
On the other hand, important biomolecules can be modified by the introduction of oxygen atoms by means of non-oxidative hydroxyl radicals.
In addition, hydroxyl radicals can reduce disulfide bonds in proteins, specifically fibrinogen, resulting in their unfolding and scrambled refolding into abnormal spatial configurations.
Consequences of this reaction are observed in many diseases such as atherosclerosis, cancer and neurological disorders, and can be prevented by the action of non-reducing substances.
Moreover, many therapeutic substances, traditionally classified as antioxidants, accept electrons and thus are effective oxidants.
It is described in this paper that hydroxyl radicals can be generated by ferric ions without any oxidizing agent.
In view of the well-known damaging effect of poorly chelated iron in the human body, numerous natural products containing iron binding agents can be essential in the maintenance of human health.
However, beneficial effects of the great number of phytochemicals that are endowed with hydroxyl radical scavenging and/or iron chelating activities should not be considered as a proof for oxidative stress.
American Psychological Association (APA)
Lipinski, Boguslaw. 2011. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499859
Modern Language Association (MLA)
Lipinski, Boguslaw. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-499859
American Medical Association (AMA)
Lipinski, Boguslaw. Hydroxyl Radical and Its Scavengers in Health and Disease. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-499859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499859