Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients
المؤلفون المشاركون
Saroglou, George
Mariolis-Sapsakos, Theodoros
Pavlidis, Christos
Vezali, Elena
Elefsiniotis, Ioannis S.
Koutsounas, Sotirios
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-04-15
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL).
Methods.
185 consecutive CHC patients (14.4% cirrhotics, 70.2% prior intravenous drug users) treated with pegylated interferon-a2b plus ribavirin, for 24 or 48 weeks based on viral genotype, were retrospectively analyzed.
SVR was confirmed by undetectable serum HCV-RNA six months after the end of treatment schedule.
Results.
Thirty percent of CHC/HBsAg-negative patients were anti-HBc-positive.
Anti-HBc positivity was more prevalent in cirrhotic, compared to noncirrhotic patients (76.9% versus 19.5%, P<.05).
Serum HBV-DNA was detected in the minority of anti-HBc-positive patients (1.97%).
Overall, 62.1% of patients exhibited SVR, while 28.6% did not; 71.4% of non-SVRs were infected with genotype 1.
In the univariate analysis, the anti-HBc positivity was negatively associated with treatment outcome (P=.065).
In the multivariate model, only the advanced stage of liver disease (P=.015) and genotype-1 HCV infection (P=.003), but not anti-HBc-status (P=.726), proved to be independent predictors of non-SVR.
Conclusion.
Serum anti-HBc positivity does not affect the SVR rates in treatment-naïve CHC patients with high pretreatment viral load, receiving the currently approved combination treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elefsiniotis, Ioannis S.& Pavlidis, Christos& Vezali, Elena& Mariolis-Sapsakos, Theodoros& Koutsounas, Sotirios& Saroglou, George. 2009. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elefsiniotis, Ioannis S.…[et al.]. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-499994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elefsiniotis, Ioannis S.& Pavlidis, Christos& Vezali, Elena& Mariolis-Sapsakos, Theodoros& Koutsounas, Sotirios& Saroglou, George. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر