Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients
Joint Authors
Saroglou, George
Mariolis-Sapsakos, Theodoros
Pavlidis, Christos
Vezali, Elena
Elefsiniotis, Ioannis S.
Koutsounas, Sotirios
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To evaluate the impact of hepatitis B core antibody (anti-HBc) seropositivity in sustained virological response (SVR) rates in treatment-naïve, chronic hepatitis C (CHC) patients with high pretreatment viral load (>800000 IU/mL).
Methods.
185 consecutive CHC patients (14.4% cirrhotics, 70.2% prior intravenous drug users) treated with pegylated interferon-a2b plus ribavirin, for 24 or 48 weeks based on viral genotype, were retrospectively analyzed.
SVR was confirmed by undetectable serum HCV-RNA six months after the end of treatment schedule.
Results.
Thirty percent of CHC/HBsAg-negative patients were anti-HBc-positive.
Anti-HBc positivity was more prevalent in cirrhotic, compared to noncirrhotic patients (76.9% versus 19.5%, P<.05).
Serum HBV-DNA was detected in the minority of anti-HBc-positive patients (1.97%).
Overall, 62.1% of patients exhibited SVR, while 28.6% did not; 71.4% of non-SVRs were infected with genotype 1.
In the univariate analysis, the anti-HBc positivity was negatively associated with treatment outcome (P=.065).
In the multivariate model, only the advanced stage of liver disease (P=.015) and genotype-1 HCV infection (P=.003), but not anti-HBc-status (P=.726), proved to be independent predictors of non-SVR.
Conclusion.
Serum anti-HBc positivity does not affect the SVR rates in treatment-naïve CHC patients with high pretreatment viral load, receiving the currently approved combination treatment.
American Psychological Association (APA)
Elefsiniotis, Ioannis S.& Pavlidis, Christos& Vezali, Elena& Mariolis-Sapsakos, Theodoros& Koutsounas, Sotirios& Saroglou, George. 2009. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499994
Modern Language Association (MLA)
Elefsiniotis, Ioannis S.…[et al.]. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-499994
American Medical Association (AMA)
Elefsiniotis, Ioannis S.& Pavlidis, Christos& Vezali, Elena& Mariolis-Sapsakos, Theodoros& Koutsounas, Sotirios& Saroglou, George. Impact of Hepatitis B Exposure on Sustained Virological Response Rates of Highly Viremic Chronic Hepatitis C Patients. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-499994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499994