Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
المؤلفون المشاركون
Hadizadeh, Shahram
Amani, Mojtaba
Niapour, Ali
Najafzadeh, Nowruz
Mansouri-Torshizi, Hassan
Mazani, Mohammad
المصدر
Biochemistry Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
As a part of a drug development program to discover novel therapeutic and more effective palladium (Pd) based anticancer drugs, a series of water-soluble Pd complexes have been synthesized by interaction between [Pd (phen)(H2O)2(NO3)2] and alkylenebisdithiocarbamate(al-bis-dtc) disodium salts.
This study was undertaken to examine the possible cytotoxic effect of three novel complexes (0.125–64 µg/mL) on human gastric carcinoma (AGS), esophageal squamous cell carcinoma (Kyse-30), and hepatocellular carcinoma (HepG2) cell lines.
The cytotoxicity was examined using cell proliferation and acridine orange/ethidium bromide (AO/EB) assay.
In order to examine the effects of new Pd(II) complexes on cell cycle status, we performed cell cycle analysis.
The complexes were found to have completely lethal effects on the cell lines, and the half maximal inhibitory concentration (IC50) values obtained for the cell lines were much lower in comparison with cisplatin.
We demonstrated that the three new Pd(II) complexes are able to induce G2/M phase arrest in AGS and HepG2; in addition, the Pd(II) complexes caused an S phase arrest in Kyse-30 cell line.
Our results indicate that newly synthesized Pd(II) complexes may provide a novel class of chemopreventive compounds for anticancer therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hadizadeh, Shahram& Najafzadeh, Nowruz& Mazani, Mohammad& Amani, Mojtaba& Mansouri-Torshizi, Hassan& Niapour, Ali. 2014. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hadizadeh, Shahram…[et al.]. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-500105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hadizadeh, Shahram& Najafzadeh, Nowruz& Mazani, Mohammad& Amani, Mojtaba& Mansouri-Torshizi, Hassan& Niapour, Ali. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر