Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
Joint Authors
Hadizadeh, Shahram
Amani, Mojtaba
Niapour, Ali
Najafzadeh, Nowruz
Mansouri-Torshizi, Hassan
Mazani, Mohammad
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As a part of a drug development program to discover novel therapeutic and more effective palladium (Pd) based anticancer drugs, a series of water-soluble Pd complexes have been synthesized by interaction between [Pd (phen)(H2O)2(NO3)2] and alkylenebisdithiocarbamate(al-bis-dtc) disodium salts.
This study was undertaken to examine the possible cytotoxic effect of three novel complexes (0.125–64 µg/mL) on human gastric carcinoma (AGS), esophageal squamous cell carcinoma (Kyse-30), and hepatocellular carcinoma (HepG2) cell lines.
The cytotoxicity was examined using cell proliferation and acridine orange/ethidium bromide (AO/EB) assay.
In order to examine the effects of new Pd(II) complexes on cell cycle status, we performed cell cycle analysis.
The complexes were found to have completely lethal effects on the cell lines, and the half maximal inhibitory concentration (IC50) values obtained for the cell lines were much lower in comparison with cisplatin.
We demonstrated that the three new Pd(II) complexes are able to induce G2/M phase arrest in AGS and HepG2; in addition, the Pd(II) complexes caused an S phase arrest in Kyse-30 cell line.
Our results indicate that newly synthesized Pd(II) complexes may provide a novel class of chemopreventive compounds for anticancer therapy.
American Psychological Association (APA)
Hadizadeh, Shahram& Najafzadeh, Nowruz& Mazani, Mohammad& Amani, Mojtaba& Mansouri-Torshizi, Hassan& Niapour, Ali. 2014. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500105
Modern Language Association (MLA)
Hadizadeh, Shahram…[et al.]. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-500105
American Medical Association (AMA)
Hadizadeh, Shahram& Najafzadeh, Nowruz& Mazani, Mohammad& Amani, Mojtaba& Mansouri-Torshizi, Hassan& Niapour, Ali. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500105