IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis

الملخص EN

IL-17B is a member of the IL-17 cytokine family which have been implicated in inflammatory response and autoimmune diseases such as rheumatoid arthritis.

The founding member of this family, IL-17 (or IL-17A), has also been implicated in promoting tumour angiogenesis through the induction of other proangiogenic factors.

Here we examine the potential of recombinant human IL-17B to contribute to the angiogenic process.

In vitro rhIL-17B was able to inhibit HECV endothelial cell-matrix adhesion and cellular migration and also, at higher concentrations, could substantially reduce tubule formation compared to untreated HECV cells in a Matrigel tubule formation assay.

This data suggests that IL-17B may act in an antiangiogenic manner.