IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
Joint Authors
Mason, Malcolm D.
Guo, Xiaoxia
Sanders, Andrew J.
Jiang, Wen G.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
IL-17B is a member of the IL-17 cytokine family which have been implicated in inflammatory response and autoimmune diseases such as rheumatoid arthritis.
The founding member of this family, IL-17 (or IL-17A), has also been implicated in promoting tumour angiogenesis through the induction of other proangiogenic factors.
Here we examine the potential of recombinant human IL-17B to contribute to the angiogenic process.
In vitro rhIL-17B was able to inhibit HECV endothelial cell-matrix adhesion and cellular migration and also, at higher concentrations, could substantially reduce tubule formation compared to untreated HECV cells in a Matrigel tubule formation assay.
This data suggests that IL-17B may act in an antiangiogenic manner.
American Psychological Association (APA)
Sanders, Andrew J.& Guo, Xiaoxia& Mason, Malcolm D.& Jiang, Wen G.. 2010. IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis. Journal of Oncology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-500496
Modern Language Association (MLA)
Sanders, Andrew J.…[et al.]. IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis. Journal of Oncology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-500496
American Medical Association (AMA)
Sanders, Andrew J.& Guo, Xiaoxia& Mason, Malcolm D.& Jiang, Wen G.. IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-500496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500496
