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Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells
المؤلفون المشاركون
Redondo, Juliana
Tredici, Giovanni
Caldara, Cristina
Carini, Fabrizio
Foudah, Dana
Miloso, Mariarosaria
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The spontaneous expression of neural markers by mesenchymal stem cells (MSCs) has been considered to be a demonstration of MSCs’ predisposition to differentiate towards neural lineages.
In view of their application in cell therapy for neurodegenerative diseases, it is very important to deepen the knowledge about this distinctive biological property of MSCs.
In this study, we evaluated the expression of neuronal and glial markers in undifferentiated rat MSCs (rMSCs) at different culture passages (from early to late).
rMSCs spontaneously expressed neural markers depending on culture passage, and they were coexpressed or not with the neural progenitor marker nestin.
In contrast, the number of rMSCs expressing mesengenic differentiation markers was very low or even completely absent.
Moreover, rMSCs at late culture passages were not senescent cells and maintained the MSC immunophenotype.
However, their differentiation capabilities were altered.
In conclusion, our results support the concept of MSCs as multidifferentiated cells and suggest the existence of immature and mature neurally fated rMSC subpopulations.
A possible correlation between specific MSC subpopulations and specific neural lineages could optimize the use of MSCs in cell transplantation therapy for the treatment of neurological diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Foudah, Dana& Redondo, Juliana& Caldara, Cristina& Carini, Fabrizio& Tredici, Giovanni& Miloso, Mariarosaria. 2012. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Foudah, Dana…[et al.]. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-500787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Foudah, Dana& Redondo, Juliana& Caldara, Cristina& Carini, Fabrizio& Tredici, Giovanni& Miloso, Mariarosaria. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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