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Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells
Joint Authors
Redondo, Juliana
Tredici, Giovanni
Caldara, Cristina
Carini, Fabrizio
Foudah, Dana
Miloso, Mariarosaria
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The spontaneous expression of neural markers by mesenchymal stem cells (MSCs) has been considered to be a demonstration of MSCs’ predisposition to differentiate towards neural lineages.
In view of their application in cell therapy for neurodegenerative diseases, it is very important to deepen the knowledge about this distinctive biological property of MSCs.
In this study, we evaluated the expression of neuronal and glial markers in undifferentiated rat MSCs (rMSCs) at different culture passages (from early to late).
rMSCs spontaneously expressed neural markers depending on culture passage, and they were coexpressed or not with the neural progenitor marker nestin.
In contrast, the number of rMSCs expressing mesengenic differentiation markers was very low or even completely absent.
Moreover, rMSCs at late culture passages were not senescent cells and maintained the MSC immunophenotype.
However, their differentiation capabilities were altered.
In conclusion, our results support the concept of MSCs as multidifferentiated cells and suggest the existence of immature and mature neurally fated rMSC subpopulations.
A possible correlation between specific MSC subpopulations and specific neural lineages could optimize the use of MSCs in cell transplantation therapy for the treatment of neurological diseases.
American Psychological Association (APA)
Foudah, Dana& Redondo, Juliana& Caldara, Cristina& Carini, Fabrizio& Tredici, Giovanni& Miloso, Mariarosaria. 2012. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500787
Modern Language Association (MLA)
Foudah, Dana…[et al.]. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-500787
American Medical Association (AMA)
Foudah, Dana& Redondo, Juliana& Caldara, Cristina& Carini, Fabrizio& Tredici, Giovanni& Miloso, Mariarosaria. Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500787