A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis

المؤلفون المشاركون

Radstake, T. R. D. J.
Geurts-van Bon, Lenny
van Hal, T. W.

المصدر

International Journal of Rheumatology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-20

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular alterations and immunological disturbances and fibrosis, the order of which remains to be fully determined.

Clinically, patients show clear signs of hypoxia in skin and internal organs.

The low oxygen tension is potentially caused by a yet to be indentified circuitry involving the three features that typify SSc.

In addition, once present, the hypoxia creates a vicious circle of ongoing pathology.

In this paper, we provide an overview of the evidence that points towards the mechanisms causing hypoxia in SSc.

In addition, data that suggest how hypoxia itself may orchestrate worsening of symptoms is presented.

Altogether, it is clear that hypoxia is an important hallmark in SSc patients.

By providing an overview of the mechanisms at play and the possible therapeutic avenues that have emerged, we hope to stimulate researchers to provide novel clues into the conundrum in SSc patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

van Hal, T. W.& Geurts-van Bon, Lenny& Radstake, T. R. D. J.. 2011. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-501104

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

van Hal, T. W.…[et al.]. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-501104

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

van Hal, T. W.& Geurts-van Bon, Lenny& Radstake, T. R. D. J.. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-501104

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-501104