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A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis
Joint Authors
Radstake, T. R. D. J.
Geurts-van Bon, Lenny
van Hal, T. W.
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular alterations and immunological disturbances and fibrosis, the order of which remains to be fully determined.
Clinically, patients show clear signs of hypoxia in skin and internal organs.
The low oxygen tension is potentially caused by a yet to be indentified circuitry involving the three features that typify SSc.
In addition, once present, the hypoxia creates a vicious circle of ongoing pathology.
In this paper, we provide an overview of the evidence that points towards the mechanisms causing hypoxia in SSc.
In addition, data that suggest how hypoxia itself may orchestrate worsening of symptoms is presented.
Altogether, it is clear that hypoxia is an important hallmark in SSc patients.
By providing an overview of the mechanisms at play and the possible therapeutic avenues that have emerged, we hope to stimulate researchers to provide novel clues into the conundrum in SSc patients.
American Psychological Association (APA)
van Hal, T. W.& Geurts-van Bon, Lenny& Radstake, T. R. D. J.. 2011. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-501104
Modern Language Association (MLA)
van Hal, T. W.…[et al.]. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-501104
American Medical Association (AMA)
van Hal, T. W.& Geurts-van Bon, Lenny& Radstake, T. R. D. J.. A System Out of Breath : How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-501104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501104