Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
المؤلفون المشاركون
Wang, Shengjun
Tian, Jie
Tong, Jia
Ma, Bin
Baidoo, Samuel Essien
Chen, Jianguo
Wu, Wei
Zhu, Chenlu
Ma, Jie
Mao, Chaoming
Lu, Liwei
Xu, Huaxi
Yang, Min
Jiao, Zhijun
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease.
So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients.
Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls.
Firstly, we found that the frequency of CD4+CXCR5+ICOShigh Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls.
It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients.
Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased.
Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Jie& Zhu, Chenlu& Ma, Bin& Tian, Jie& Baidoo, Samuel Essien& Mao, Chaoming…[et al.]. 2012. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Jie…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-501339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Jie& Zhu, Chenlu& Ma, Bin& Tian, Jie& Baidoo, Samuel Essien& Mao, Chaoming…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر