Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
Joint Authors
Wang, Shengjun
Tian, Jie
Tong, Jia
Ma, Bin
Baidoo, Samuel Essien
Chen, Jianguo
Wu, Wei
Zhu, Chenlu
Ma, Jie
Mao, Chaoming
Lu, Liwei
Xu, Huaxi
Yang, Min
Jiao, Zhijun
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease.
So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients.
Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls.
Firstly, we found that the frequency of CD4+CXCR5+ICOShigh Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls.
It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients.
Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased.
Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA.
American Psychological Association (APA)
Ma, Jie& Zhu, Chenlu& Ma, Bin& Tian, Jie& Baidoo, Samuel Essien& Mao, Chaoming…[et al.]. 2012. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501339
Modern Language Association (MLA)
Ma, Jie…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-501339
American Medical Association (AMA)
Ma, Jie& Zhu, Chenlu& Ma, Bin& Tian, Jie& Baidoo, Samuel Essien& Mao, Chaoming…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501339