Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death
المؤلفون المشاركون
Bhattacharyya, Sudip
Das, Joydeep
Ghosh, Jyotirmoy
Manna, Prasenjit
Sil, Parames C.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-13
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Present study investigates the beneficial role of the aqueous extract of the fruits of Pithecellobium dulce (AEPD) against carbon tetrachloride (CCl4)-induced hepatic injury using a murine model.
AEPD has been found to possess free radical (DPPH, hydroxyl and superoxide) scavenging activity in cell-free system.
CCl4 exposure increased the activities of various serum maker enzymes and intracellular reactive oxygen species (ROS) production.
In line with these findings, we also observed that CCl4 intoxication increased the lipid peroxidation and protein carbonylation accompanied by decreased intracellular antioxidant defense, activity of cytochrome P450 and CYP2E1 expression.
DNA fragmentation and flow cytometric analyses revealed that CCl4 exposure caused hepatic cell death mainly via the necrotic pathway.
Treatment with AEPD both pre- and post-toxin exposure protected the organ from CCl4-induced hepatic damage.
Histological findings also support our results.
A well-known antioxidant vitamin C was included in this study to compare the antioxidant potency of AEPD.
Combining all, results suggest that AEPD protects murine liver against CCl4-induced oxidative impairments probably via its antioxidative property.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manna, Prasenjit& Bhattacharyya, Sudip& Das, Joydeep& Ghosh, Jyotirmoy& Sil, Parames C.. 2011. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manna, Prasenjit…[et al.]. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-501786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manna, Prasenjit& Bhattacharyya, Sudip& Das, Joydeep& Ghosh, Jyotirmoy& Sil, Parames C.. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-501786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر