Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death
Joint Authors
Bhattacharyya, Sudip
Das, Joydeep
Ghosh, Jyotirmoy
Manna, Prasenjit
Sil, Parames C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Present study investigates the beneficial role of the aqueous extract of the fruits of Pithecellobium dulce (AEPD) against carbon tetrachloride (CCl4)-induced hepatic injury using a murine model.
AEPD has been found to possess free radical (DPPH, hydroxyl and superoxide) scavenging activity in cell-free system.
CCl4 exposure increased the activities of various serum maker enzymes and intracellular reactive oxygen species (ROS) production.
In line with these findings, we also observed that CCl4 intoxication increased the lipid peroxidation and protein carbonylation accompanied by decreased intracellular antioxidant defense, activity of cytochrome P450 and CYP2E1 expression.
DNA fragmentation and flow cytometric analyses revealed that CCl4 exposure caused hepatic cell death mainly via the necrotic pathway.
Treatment with AEPD both pre- and post-toxin exposure protected the organ from CCl4-induced hepatic damage.
Histological findings also support our results.
A well-known antioxidant vitamin C was included in this study to compare the antioxidant potency of AEPD.
Combining all, results suggest that AEPD protects murine liver against CCl4-induced oxidative impairments probably via its antioxidative property.
American Psychological Association (APA)
Manna, Prasenjit& Bhattacharyya, Sudip& Das, Joydeep& Ghosh, Jyotirmoy& Sil, Parames C.. 2011. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501786
Modern Language Association (MLA)
Manna, Prasenjit…[et al.]. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-501786
American Medical Association (AMA)
Manna, Prasenjit& Bhattacharyya, Sudip& Das, Joydeep& Ghosh, Jyotirmoy& Sil, Parames C.. Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-501786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501786