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Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis
المؤلفون المشاركون
Rovaris, Marco
Vaghi, M.
Zaffaroni, M.
Meazza, C.
Gironi, M.
Solaro, C.
Albertini, R.
Nemni, R.
Bozzola, Mauro
Montagna, L.
Batocchi, Anna Paola
المصدر
Multiple Sclerosis International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Evidence suggests that neurohormones such as GH and IGF-I are involved in the neuroreparative processes in multiple sclerosis (MS).
GH and IGF-I blood levels in naïve MS patients with different disease courses were investigated in this study.
Serum GH and IGF-I in untreated MS patients (n=64), healthy controls (HC, n=62), and patients affected by other neurological diseases (OND, n=46) were evaluated with a solid-phase-enzyme-labeled-chemiluminescent-immunometric assay.
No differences were detected in GH across MS, OND, and HC (MS=0.87±1.32 ng/mL; OND=1.66±3.7; and HC=1.69±3.35; P=0.858) when considering gender, disease duration, and disease course.
However, GH was lower (P=0.007) in patients with more severe disease (expanded disability scale score, EDSS≥4.0) compared with milder forms (EDSS<4).
IGF-I l did not differ across the 3 groups (P=0.160), as far as concern disease course, disability, and gender were.
Lower IGF-I levels were detected in subjects older than 50 years compared to younger ones for all 3 groups.
Lower GH was detected in patients with more severe MS, and age was confirmed as the main factor driving IGF-I levels in all subjects.
These findings, relying on the natural course of the disease, could help in shedding lights on the mechanisms involved in autoreparative failure associated with poorer prognosis in MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gironi, M.& Solaro, C.& Meazza, C.& Vaghi, M.& Montagna, L.& Rovaris, Marco…[et al.]. 2013. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gironi, M.…[et al.]. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-502025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gironi, M.& Solaro, C.& Meazza, C.& Vaghi, M.& Montagna, L.& Rovaris, Marco…[et al.]. Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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