Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats
المؤلفون المشاركون
Han, Jin-Yi
Lee, Kinam
Hu, Zhenzhen
Lee, Chung-Il
Oh, Eun-Hye
Hong, Jin Tae
Shah, Vikash Kumar
Chong, Myong-Soo
Bae, Jae-Ryong
Oh, Ki-Wan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analogue and one of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus Cordyceps.
It has traditionally been a prized Chinese folk medicine for the human well-being.
Because of similarity of chemical structure of adenosine, cordycepin has been focused on the diverse effects of the central nervous systems (CNSs), like sleep regulation.
Therefore, this study was undertaken to know whether cordycepin increases the natural sleep in rats, and its effect is mediated by adenosine receptors (ARs).
Sleep was recorded using electroencephalogram (EEG) for 4 hours after oral administration of cordycepin in rats.
Sleep architecture and EEG power spectra were analyzed.
Cordycepin reduced sleep-wake cycles and increased nonrapid eye movement (NREM) sleep.
Interestingly, cordycepin increased θ (theta) waves power density during NREM sleep.
In addition, the protein levels of AR subtypes (A1, A2A, and A2B) were increased after the administration of cordycepin, especially in the rat hypothalamus which plays an important role in sleep regulation.
Therefore, we suggest that cordycepin increases theta waves power density during NREM sleep via nonspecific AR in rats.
In addition, this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Zhenzhen& Lee, Chung-Il& Shah, Vikash Kumar& Oh, Eun-Hye& Han, Jin-Yi& Bae, Jae-Ryong…[et al.]. 2013. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502353
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Zhenzhen…[et al.]. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502353
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Zhenzhen& Lee, Chung-Il& Shah, Vikash Kumar& Oh, Eun-Hye& Han, Jin-Yi& Bae, Jae-Ryong…[et al.]. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502353
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502353
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر