Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats
Joint Authors
Han, Jin-Yi
Lee, Kinam
Hu, Zhenzhen
Lee, Chung-Il
Oh, Eun-Hye
Hong, Jin Tae
Shah, Vikash Kumar
Chong, Myong-Soo
Bae, Jae-Ryong
Oh, Ki-Wan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analogue and one of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus Cordyceps.
It has traditionally been a prized Chinese folk medicine for the human well-being.
Because of similarity of chemical structure of adenosine, cordycepin has been focused on the diverse effects of the central nervous systems (CNSs), like sleep regulation.
Therefore, this study was undertaken to know whether cordycepin increases the natural sleep in rats, and its effect is mediated by adenosine receptors (ARs).
Sleep was recorded using electroencephalogram (EEG) for 4 hours after oral administration of cordycepin in rats.
Sleep architecture and EEG power spectra were analyzed.
Cordycepin reduced sleep-wake cycles and increased nonrapid eye movement (NREM) sleep.
Interestingly, cordycepin increased θ (theta) waves power density during NREM sleep.
In addition, the protein levels of AR subtypes (A1, A2A, and A2B) were increased after the administration of cordycepin, especially in the rat hypothalamus which plays an important role in sleep regulation.
Therefore, we suggest that cordycepin increases theta waves power density during NREM sleep via nonspecific AR in rats.
In addition, this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects.
American Psychological Association (APA)
Hu, Zhenzhen& Lee, Chung-Il& Shah, Vikash Kumar& Oh, Eun-Hye& Han, Jin-Yi& Bae, Jae-Ryong…[et al.]. 2013. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502353
Modern Language Association (MLA)
Hu, Zhenzhen…[et al.]. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502353
American Medical Association (AMA)
Hu, Zhenzhen& Lee, Chung-Il& Shah, Vikash Kumar& Oh, Eun-Hye& Han, Jin-Yi& Bae, Jae-Ryong…[et al.]. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502353