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Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia
المؤلفون المشاركون
Nunes Santiago, Amanda
Godoi-Gazola, Vilma Aparecida Ferreira de
Fachin Milani, Mariana
Diaz Pedrosa, Maria Montserrat
Bazotte, Roberto Barbosa
de Campos, Vanessa Cristina
Rodrigues Vilela, Vanessa
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The effect of the oral administration of blood glucose precursors on glycemia recovery and liver glucose production in fasted mice subjected to insulin-induced hypoglycemia (IIH) was investigated.
IIH was obtained with increasing doses (from 0.5 to 2.0 U·kg−1) of intraperitoneal regular insulin where glycemia was evaluated from 0 to 300 min after insulin injection.
The dose of 1.0 U·kg−1 showed the best results, that is, a clear glycemia recovery phase without convulsions or deaths.
Thus, this dose was used in all experiments.
Afterwards, mice submitted to IIH received orally by gavage: saline (control group), glucose (100 mg·kg−1), glycerol (100 mg·kg−1), lactate (100 mg·kg−1), alanine (100 mg·kg−1), or glutamine (100 mg·kg−1).
It was observed that glutamine was more effective in promoting glycemia recovery if compared with glucose, lactate, glycerol, or alanine.
In agreement with these results, the best performance in terms of liver glucose production was obtained when glutamine was used as glucose precursors.
These results open perspectives for clinical studies to investigate the impact of oral administration of gluconeogenic amino acids to promote glycemia recovery during hypoglycemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nunes Santiago, Amanda& Godoi-Gazola, Vilma Aparecida Ferreira de& Fachin Milani, Mariana& de Campos, Vanessa Cristina& Rodrigues Vilela, Vanessa& Diaz Pedrosa, Maria Montserrat…[et al.]. 2013. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502500
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nunes Santiago, Amanda…[et al.]. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-502500
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nunes Santiago, Amanda& Godoi-Gazola, Vilma Aparecida Ferreira de& Fachin Milani, Mariana& de Campos, Vanessa Cristina& Rodrigues Vilela, Vanessa& Diaz Pedrosa, Maria Montserrat…[et al.]. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502500
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502500
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